NANOCOMPOSITE HYDROGELS WITH EMBEDDED MINERAL NANOPARTICLES

2018;
136-141
1
Lviv Polytechnic National University
2
Lviv Polytechnic National University
3
Lviv Polytechnic National University
4
Lviv Polytechnic National University
5
Lviv Polytechnic National University

Cross-linked nanocomposite hydrogels based on polyacrylamide and mineral
nanoparticles of hydroxyapatite, ZnO, TiO2 previously modified by reactive polymers were
synthesized via the method of polymerization filling. It is shown that physico-mechanical
properties of obtained nanocomposites are determined to a great extent by the nature of the
modifier of mineral nanoparticles. The influence of the nature of mineral filler as well as of
reactive modifier of nanoparticle surface onto colloidal-chemical and physio-mechanical
properties of nanocomposite hydrogels was studied. Obtained hydrogels are characterized by
rather high physio-mechanical properties.

1. Gaharwar A. K., Peppas N. A., Khademhosseini A. Nanocomposite hydrogels for biomedical
applications // Biotech & Bioeng. – 2014. – Vol. 111(3). – P. 441–453. 2. Ha Y., Shih H., Munoz Z.
141
et al. Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture // Acta
Biomaterialia. – 2014. – Vol. 10. – P. 104–114. 3. Haraguchi K. Nanocomposite hydrogels // Current
Opinion in Solid State and Materials Science. – 2007. – Vol. 11 (3–4). – P. 47–54. 4. Haraguchi K.,
Takehisa T. Nanocomposite Hydrogels: A Unique Organic–Inorganic Network Structure with
Extraordinary Mechanical, Optical, and Swelling/Deswelling Properties // Advanced Materials. – 2002. –
Vol. 14 (16). – P. 1120–1124. 5. Merino S., Martín C., Kostarelos K. et al. Nanocomposite hydrogels:
3D polymer–nanoparticle synergies for on-demand drug delivery // ACS Nano. – 2015. – Vol. 9 (5). –
P. 4686–4697. 6. Satarkar N. S., Biswal D., Hilt J. Z. Hydrogel nanocomposites: a review of applications
as remote controlled biomaterials // Soft Matter. – 2010. – Vol. 6. – P. 2364–2371. 7. Schexnailder P.,
Schmidt G. Nanocomposite polymer hydrogels // Colloid Polym. Sci. – 2009. – Vol. 287. – P. 1–11.
8. Gaharwar A. K., Peppas N. A., Khademhosseini A. Nanocomposite hydrogels for biomedical
applications // Biotechnol. Bioeng. – 2014. – Vol. 111. – P. 441–453. 9. Thoniyot P., Tan M. J, Karim
A. A. et al. Nanoparticle–hydrogel composites: concept, design, and applications of these promising,
multi-functional materials // Adv. Sci. – 2015. – Vol. 2. – P. 1400010-1–1400010-13. 10. Курганс-
кий В. С., Пучин В. А., Воронов С. А., Токарев В. С. Синтез гетерофункциональных полимеров с
пероксидными и ангидридными группами // Высокомол. соед. – 1983. – Т (А) 25. – № 5. –
С. 997–1004. 11. Торопцева А. М., Белогородская К. В., Бондаренко В. М. Лабораторный практикум
по химии и технологии высокомолекулярных соединений. – Л.: Химия, 1972. – 416 с.