Quinoline and its derivatives are important compounds for the chemical synthesis and development of novel drugs. Practical application of a number of substances with quinoline heterocycle is already known in medical practice. We performed predictive screening for biological activity, cytotoxic and toxic effects on rats of synthesized 8-quinoline thiosulfonic acid S-alkyl esters using appropriate on-line programs.They have been found to be low-toxic substances with a broad spectrum of biological action and a high probability of activity, which indicates the expediency of continuing experimental studies of their properties. Particular attention should be paid to the methyl and ethyl esters of 8-quinolintiosulfonic acids.
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