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  2. All Volumes and Issues
  3. Volume 14, Number 2, 2020
  4. The Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety

The Synthesis and In Silico Antihypertensive Activity Prognosis of New Mannich Bases Containing the 1,2,4-Triazole Moiety

JCCT.
2020;
Volume 14, Number 2
: pp. 214 - 220
https://doi.org/10.23939/chcht14.02.214
Authors:
  1. Lina Perekhoda
  2. Victoriya Georgiyants
  3. Hanna Yeromina
  4. Iryna Drapak
  5. Vira Lubenets
  6. Zinaida Ieromina
  7. Irina Sych
  8. Hanna Severina
  9. Anatoly Demchenko
1
National University of Pharmacy
2
National University of Pharmacy
3
National University of Pharmacy
4
Danylo Halytsky Lviv National Medical University
5
Lviv Polytechnic National University
6
National University of Pharmacy
7
National University of Pharmacy
8
National University of Pharmacy
9
Institute of Pharmacology and Toxicology, National Academy of Medical Sciences; Nizhyn Mykola Gogol State University

As a part of our continuous research on potential antihypertensive agents among morpholine and piperidine derivatives, 10 novel target compounds containing 1,2,4-triazole and morpholine or piperidine moieties have been designed and synthesized, and the docking studies have been conducted in order to find biologically active substances with the antihypertensive activity. The in silico studies have shown that all compounds synthesized are promising angiotensin converting enzyme inhibitors and belong to the toxicity class 4 and 5 according to the classification of chemicals by the OECD project.

Mannich bases
1, 2, 4-triazole
synthesis
antihypertensive activity
in silico prognosis
docking studies
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