Study of Kinetics of Medicinal Substances Release from Chitosan Films

Authors: 

Angela Shurshina, Elena Kulish and Roman Lazdin

Bashkir State University, 32, Zaki Validi str., 450074 Ufa, Russia; alenakulish@rambler.ru

The kinetics of controlled release of medicinal substances from chitosan films has been investigated. Correlation between values of diffusion coefficients and the sedate indicator characterizing diffusion of medicinal substance from a film and shares of medicinal substance connected with a polymeric chain has been established. With the increase in amount of the entered medicinal substance the rate of release of medicines decreases.

[1] Iordansky A., Shterezon A., Moiseev Yu. and Zaikov G.: Uspekhi Khimii, 1979, XLVIII, 1460.
[2] Crank J.: The Mathematics of Diffusion. Clarendon Press, Oxford 1975.
[3] Livshic V., Bonarcev A., Iordansky A. et al.: Vysokomol. Soedin., 2009, 51, 7, 1251.
[4] Malkin A. and Tchalykh A.: Diffuziya i Vyazkost Polimerov. Metody Izmereniya. Khimiya, Moskwa 1979.
[5] Pomerantsev A.: Doct. thesis, Mosk. Gos. Univ., Moskwa 2003.
[6] Smotrina T.: Butlerov. Soobshch., 2012, 29, 2, 101.