computer screening

In order to explore the possibility of expanding the range of use of complex biologically active compounds of wild carrot an initial screening of phytochemical composition and antimicrobial activity of water and ethanol extract from seeds of wild carrot was conducted and computer screening of biological activity of active substances by program PASS was carried out. In the investigated extract chlorogenic, caffeic, rosemary acids, rutin, apigenin, luteolin, hyperoside were identified.

The reactions of 1,4(1,5)-diazido-9,10-anthracenediones with phenylacetylene and methyl propiolate under copper(I)-catalyzed reaction of the azide-alkyne cycloaddition conditions have been studied and a series of new 1,2,3-triazole derivatives of 9,10-anthracendione have been obtained. The computer screening of synthesized compounds was carried out using the PASS Online software to identify areas of experimental biomedical researches.