gelatin

The formation of the hydrogel polymer matrix duringthe gelatin cross-linking with dioxirane derivatives of polyoxyethylene glycolswere studied.The optimal conditions for their synthesis were determined. The characteristics of the hydrogel (swelling in different media, mechanical properties at different temperatures) were obtained depending on the type of dioxirane derivative and prepolymer ratio. The possibility of introducing several drugs into hydrogels was established and the release of these drugs was found to be prolonged.

Modern hydrogel healing therapies for damaged human skin, must perform a number of functions which are inherent for the skin: 1) preservation of thermal and water balance; 2) ensuring of oxygen penetration; 3) providing transportation of substances necessary for the functioning of the organism; 4) protection from mechanical damage. When using hydrogel coatings on damaged areas of the skin, they must perform, an additional function - prolonged delivery to the wound of therapeutic agents of various nature.

Hydrogels are one of the perspective classes of polymer systems that embrace numerous biomedical and pharmaceutical applications. Hydrogels have become very popular due to its unique properties such as high water content, softness, elasticity and biocompatibility. Natural and synthetic hydrophilic polymers can be physically or chemically crosslinked to obtain hydrogels. Their resemblance to living tissue opens up many possibilities for applications in biomedical fields.

The regularities of binding substances of aromaforming cryo- and thermotropic jellies of gelatin and starch were studied. The influence of the surface of hydrophobic jelly on their ability to absorb aqueous solutions of thymol was experimentally confirmed. The reduction of sorption by thymol cryotropic jellies versus the thermotropic one was established. Experimentally it was confirmed that the most promising technology to create flavors from aromatic hydrophobic substances are thermotropic jellies y of gelatin with high hydrophobicity.