поліетиленгліколь

Ultrafine phase change nanofibers based on polyethylene glycol 1000 (PEG1000) as phase change material (PCM) and polyamide 6 (PA6) as a supporting material were prepared in a systematic manner planned by the Design-Expert® software using the uniaxial electros-pinning. Research surface methodology (RSM) was carried out to optimize the parameters and conditions leading to minimize the fiber diameter. The effect of PEG content, applied voltage, needle gauge, and flow rate on the fiber characteristics was studied by a central composite design (CCD).

Poly(phosphoeter)s (PPE)s are a class of polymers possessing a high chemical functionality and biodegradability. Novel, glutamic acid based poly(phosphoeter)s were synthesized by the Steglich reaction. The developed synthetic approach allows controlling the composition and the structure of PPEs, and therefore their physical and colloidal properties. The studies on solubilization and cytotoxicity in vitro proved the potential of PPEs for drug delivery applications.

The actual problem in medicine is a phenomenon of antibiotic resistance, therefore, it is expedient to develop and introduce new antibiotics or to improve the transport of already known antibiotics into the cell. PEGylating is the one of the most successful ways of improving of the delivery of therapeutic molecules to the cell, such as proteins, oligonucleotides and other biomolecules. Thus, it is promising to introduce PEG fragments into the structure of antibiotics with the preservation of their biological activity.

На основі дизаміщених оксетанів синтезовано b-гідроксилвмісні пероксиди.
Вивчено вплив умов проведення реакції на вихід та склад продуктів взаємодії.
Отримані пероксиди використано як вихідні сполуки для одержання нових поверхнево-
активних речовин ряду несиметричних естерів малеїнової кислоти, які містять як
гідрофобну складову w-трет-бутилпероксиалкільний радикал, а гідрофільною складо-
вою є поліетиленґліколевий фрагмент. Досліджено поверхнево-активні властивості
синтезованих ПАРмерів. Будову отриманих сполук підтверджено та охарактеризовано