ITRIAZENES ON THE BASIS OF 4-IMIDAZOLE SUBSTITUTED ANTRAQUINONE AS THE POTENTIAL INHIBITORS OF PROTEINS

2019;
: 135-141
1
Vasyl Stefanyk Precarpathian National University
2
Vasyl Stefanyk Precarpathian National University
3
Vasyl Stefanyk Precarpathian National University
4
Lviv Polytechnic National University
5
Lviv Polytechnic National University

The article by authors Shupeniuk V.I., Taras T.M., Sabadakh O.P., Bolibruch L.D., Zhurakhivska L.R. “Triazenes on the basis of 4-imidazole substituted antraquinone as the potential inhibitors of proteins” devoted to the study of the structure of triazenes on the basis of 4-imidazole substituted 9,10-anthraquinone, depending on the calculation of their probable effect on proteins using the DIGEP-Pred program. In the article, the authors cover problems arising during the synthesis of triazene derivatives on the basis of 1-amino-4-(1H-imidazol-1-yl)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid. Authors in the article give convenient methods of diazotization of 4-substituted derivatives 9,10-anthraquinone, which developed based on the analysis of literature’s sources and own experimental data. With the synthesized diazo-compounds, the authors of the article carried out the reaction of N-azocoupling with aliphatic, aromatic and heterocyclic aromatic amines with maximum yield.

The article by authors Shupeniuk V.I., Taras T.M., Sabadakh O.P., Bolibruch L.D., Zhurakhivska L.R. consists of four parts. In the first part, the authors substantiate the purpose of the described research, show the need for the synthesis of new nitrogen-containing derivatives 9,10-anthraquinone. The second part of the article describes the methods and characteristics of the substances obtained by physico-chemical analysis, as well as data on the devices and methods of analysis. The formation of the desired triazenes has been confirmed by chromatomass spectrometry data and 1H- and 13C-NMR spectroscopy, which is presented in the experimental part along with the synthesis methods. In the third part, the authors direct their research, give their discussion and analysis. The authors of the article provide data on the computerized toxicity prediction using the online ROSC-Pred program (web-service for rodent organ-specific carcinogenicity prediction), prediction of rodent carcinogens taking into account the species (rats, mice), specificity from the structural formula of compounds. And also the method of diazotization of 4-imidazole substituted 9,10-anthraquinone is obtained by nucleophilic substitution of bromine in brominic acid. The proposed diazotization techniques allow the N-azo-reaction with aliphatic, aromatic, and heterocyclic aromatic amines to react with the maximum yield in the presence of polyethylene glycol-400 to produce triazenes. The article concludes with the conclusions and list of used literary sources.

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