Effect of Polystyrene/Fullerene Composites on the Lipid Peroxidation in Blood Serum

Authors: 
Olga Alekseeva, Olga Sitnikova, Nadezhda Bagrovskaya and Andrew Noskov

Olga Alekseeva-1, Olga Sitnikova-2, Nadezhda Bagrovskaya-1 and Andrew Noskov-1

  1. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 Akademicheskaya St., 153045 Ivanovo, Russia; ova@isc-ras.ru
  2. V.N. Gorodkov Research Institute of Maternity and Childhood, 20 Pobedy St., 153045 Ivanovo, Russia

Pure polystyrene films and polystyrene films filled with fullerenes (C60+C70 mix) were fabricated by the solution cast method. Effect of polystyrene/fullerene composite on free-radical processes in blood serum has been investigated in vitro. The parameters of lipid peroxidation in native serum after adding the composite films were determined by a chemiluminescent analysis and spectrophotometry. It was revealed that fullerene-containing nanocomposites can manifest antioxidant activity in blood serum

[1] Chakraborty M., Jain S. and Rani V.: Appl. Biochem. Biotechnol., 2011, 165, 1178.
[2] Kroto H., Heat J., O’Brien S. et al.: Nature, 1985, 318, 162.
[3] Bezmel'nitsyn V., Eletskii A. and Okun' M.: Uspekhi Phys. Nauk, 1998, 41, 1091.
[4] Andreev I., Petrukhina A., Garmanova A. et al.: Fuller. Nanotub. Car., 2008, 16, 89.
[5] Da Ros T.: Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes [in:] Cataldo F. and Da Ros T. (Eds.), Carbon Materials: Chemistry and Physics, vol. 1. Springer Int. Publ AG, 2008, 1-21.
[6] Wong-Ekkabut J., Baoukina S., Triampo W. et al.: Nat. Nano, 2008, 3, 363.
[7] Foley S., Crowley C., Smaihi M. et al.: Biochem. Biophys. Res. Commun., 2002, 294, 116.
[8] Piotrovskiy L., Eropkin M., Eropkina E. et al.: Psychopharmacol. Biol. Narcol., 2007, 2, 1548.
[9] Lyon D., Adams L., Falkner J. and Alvarez P.: Environ. Sci. Technol., 2006, 40, 4360.
[10] Verner R. and Benvegnu C. (Eds.): Handbook on Fullerene: Synthesis, Properties and Applications. Nova Science Publishers, Inc. New York 2012.
[11] Weng D., Lee H., Levon K. et al.: Eur. Polym. J., 1999, 35, 867.
[12] Badamshina E. and Gafurova M.: Polym. Sci. B, 2008, 50, 215.
[13] Alekseeva O., Barannikov V., Bagrovskaya N. and Noskov A.: J. Therm. Anal. Calor., 2012, 109, 1033.
[14] Alekseeva O., Bagrovskaya N., Kuz'min S. et al.: Russ. J. Phys. Chem. A., 2009, 83, 1170.
[15] Alekseeva O., Bagrovskaya N., Kuz'min S. et al.: Doklady Phys. Chem., 2008, 422, 275.
[16] Okovitiy S.: FARMindex: Praktik, 2003, 5, 85.
[17] Evlampieva N., Zaitseva I., Ryumtsev E. et al.: Polymer Sci. A., 2007, 49, 284.
[18] Ishihara M.: Clin. Chim. Acta, 1978, 84, 1.
[19] Promyslov Sh. and Demchuk M.: Voprosy Meditsinskoi Khim., 1990, 36, 90.
[20] Zhou X., Liu J., Jin Z. et al.: Fullerene Sci. Techn., 1997, 5, 285.