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  3. Volume 14, Number 3, 2020
  4. Synthesis and Evaluation of Hypoglycemic Activity of New Pyrazolothiazolidine Hybrid Structures

Synthesis and Evaluation of Hypoglycemic Activity of New Pyrazolothiazolidine Hybrid Structures

JCCT.
2020;
Volume 14, Number 3
: pp. 284 - 289
https://doi.org/10.23939/chcht14.03.284
Authors:
  1. Nadiya Panasenko
  2. Mykhailo Bratenko
  3. Viktor Zvarych
  4. Maryna Stasevych
  5. Mykhailo V. Vovk
1
Bucovinian State Medical University
2
Bucovinian State Medical University
3
Lviv Polytechnic National University
4
Lviv Polytechnic National University
5
Institute of Organic Chemistry, NAS of Ukrainе

New promising pyrazolothiazolidine hybrid structures, containing a methylenehydrazone linker between functionalized pyrazole and thiazolidine cycles, have been obtained using cyclocondensation of 3-aryl-4-formylpyrazole thiosemicarbazones and diethyl acetylenedicarboxylate in mild reactional conditions. The acetic acid was proposed as a catalytic agent for the synthesis of ambident bi-center thiosemicarbazones as reagents for further formation of the thiazolidine cycle. The obtained pyrazolothiazolidines were found to exhibit hypoglycemic activity by in vivo study of glucose level in the blood of rats after oral administration of synthesized derivatives

pyrazoles
thiazolidinones
hybrid structures
hypoglycemic activity
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