DEVELOPMENT OF THE BASICS OF PRODUCTION TECHNOLOGY OF DACARBAZINE SUBSTANCE WITH ANTICANCER EFFECT
The basics of the technology for the production of dacarbazine, which is an active ingredient in medicines for the treatment of metastatic melanoma, Hodgkin's lymphoma, and soft tissue sarcoma, are presented. Based on the laboratory methodology, the production was scaled up as a periodic production with a capacity of 35 tons per year to produce 1 ton of the substance from commercially available reagents. Six main technological stages of production were selected, which allowed to obtain a product with a yield of 86%.