acid hydrolysis

Development of the technological basis for the production of aceclofenac

Aceclofenac drugs are widely used in the global therapeutic practice of inflammatory and painful conditions for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in various dosage forms. The basics of the technology of domestic industrial batch production of aceclofenac with a capacity of 110 t/year for the production of a number of effective medicines have been developed. A five-stage production process is proposed that will allow the production of a domestic product with a high yield (~ 91%) from commercially available reagents.

Acid Hydrolysis and Ethanol Precipitation for Glucomannan Extraction from Crude Porang (Amorphophallus Oncophyllus) Tuber Flour

Extraction of glucomannan from crude porang flour by acid hydrolysis and ethanol precipitation was studied. Effects of acid concentration, temperatures and time were investigated, kinetics model of the process was developed and the parameters were evaluated based on experimental data. New data on yield and purity of glucomannan under various conditions were obtained.