hydrophilic-lipophilic balance

The distribution coefficients of macromolecules of aminofunctional copolyesters with chromophore groups in the n-octanol–water system, as well as experimental and calculated characteristics of their hydrophilic-lipophilic balance (HLB) have been determined. A multiple regression analysis has been carried out and interpolation equation of the lipophilicity coefficient has been derived depending on the parameters characterizing the qualitative and quantitative composition of the copolyester.

In recent years, nanoscale forms, except targeted drug delivery to the pathological sites for therapy, can  be functionalized with drugs as well as fluorescent substances therefore their diagnostics and therapeutic potential is enormous. Such nanoscale forms usually are formed due to the self-assembly of biocompatible amphiphilic block copolymers in an aqueous medium. In this case lipophilic fragments of polymer macromolecules form nanocarrier core which can be loaded with molecules of lipophilic drugs.