ZnCl2-Catalyzed Four-Component Domino Reaction for One-Pot Eco-Safe and Convenient Synthesis of Polyfunctionalized Dihydro-2-oxopyrroles at Ambient Temperature
In this study, ZnCl2 was applied as an environmentally friendly and efficient Lewis acid catalyst for the one-pot four-component synthesis of polysubstituted dihydro-2-oxopyrroles from the reaction between dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) at ambient temperature. This methodology has a number of advantages such as use of inexpensive, eco-safety of catalyst, short reaction times, high yields, easy work-up (just simple filtration), and simplicity of operation.