thin-layer chromatography; naphthoquinone-1

The chromatographic characteristics are investigated for eight aromatic derivatives of 3-chloro-1,4-naphthoquinone under conditions of normal-phase thin-layer chromatography for benzene-based binary mobile phase and such polar solvents as chloroform, acetone, acetonitrile, methanol and propan-2-ol. The slope of linear retention dependencies for the investigated compounds on the concentration of the polar component in the mobile phase satisfactorily correlates with the area occupied by the adsorbed analyte molecule in the stationary phase.

Amino derivatives of 3-chloro-1,4-naphthoquinone exhibit certain types of biological activity, in particular antibacterial, antifungal, as well as chelating activity for the transport of trace elements, due to the presence in the structure of the quinidic fragment and the corresponding substituents.