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The values of еffective rate constants of microorganisms destruction (kd) were compared, depending on the diameter of cells and gas nature bubbling under cavitation conditions. The efficiency of cell destruction under Ar/US is larger by 2–2.5 times compared to He/US, O₂/US and CO₂/US. Yeast cells were destroyed faster than bacteria (kd (yeast cells) >> kd (bacteria cells)) that is explained by the cells size. The cell stability under cavitational conditions is reversely proportional to the cell diameter.

The disinfection of water from Diplococcus, S.lutea, B.cereus, and Ps.fluorescens bacteria types and the yeast Sacch.cerevisiae via the joint action of gas/US has been investigated. The investigated microorganisms were identified in natural water and wastewater in dominant amounts. The relative ranges of effective cell destruction by combined gas/US action have been established.