chitosan

Chitosan films obtained from solutions in acetic acid and containing the antibiotics – cephazolin and cephotoxim – have been investigated and the principal possibility of regulating their transport properties as regards the medicinal preparations release has been demonstrated. This regulation can be carried out by films thermal modification consisting in heating of the formed films at the temperature of about 393 K and their treatment with sodium dodecylsulphate solution.

The kinetics of controlled release of medicinal substances from chitosan films has been investigated. Correlation between values of diffusion coefficients and the sedate indicator characterizing diffusion of medicinal substance from a film and shares of medicinal substance connected with a polymeric chain has been established. With the increase in amount of the entered medicinal substance the rate of release of medicines decreases.

Some ways of estimating the values of the intrinsic viscosity of chitosan were analyzed. It was shown that the method of Irzhak and Baranov for estimating the current value of the intrinsic viscosity allows to adequately estimates the conformational state of the macromolecular coil and its degree of swelling.

The purification of biodiesel was performed using glutaraldehyde-crosslinked chitosan membrane to improve the quality and to reduce the cost of biodiesel production. Biodiesel was obtained by acid-based catalyzed transesterification of Calophyllum inophyllum oil. The results of this experiment showed that the amount of glycerol in biodiesel before the process is 0.3014±0.05 %. After the purification process performed for 1 h, the glycerol content in biodiesel has been reduced to 0.1429±0.09 %.