synthesis

The synthesis and antitumor activity screening of 1,2,4-triazino[5,6-b]indoles based conjugates were performed. Reaction between 3-mercapto-1,2,4-triazino[5,6-b]indoles and several N-arylchloroacetamides yielded 3S-substituted 1,2,4-triazino[5,6-b]indoles. Based on 3-hydrazine-1,2,4-triazino[5,6-b]indoles the new 4-thiazolidinones have been synthesized. Seven synthesized compounds were tested for their anticancer activity in NCI60 cell lines.

The interaction of pyridine-4(-3,-2)aldoxime has been studied whit 3-bromo-N,N,N-trialkyl-2-oxo(-hydroxyimino)-1-propanaminium bromide. The structure of all synthesized compounds was determined by elemental analysis as well as by physical and chemical methods. All synthesized compounds were tested for reactivation of phosphorylated acetylcholinesterase.