Evaluating Binol-Aldehyde as a Chiral Derivatizing Agent for Diamines
We have synthesized and tested a new binol-aldehyde compound 1, against five diamine compounds. Using 1H NMR (400 MHz) spectroscopy, stable diasteriomeric imine complexes between 1 and five diamines were formed. Chemical shift nonequivalences (up to 0.058 ppm) were obtained for imines. Linear calibration plot was obtained for determining the enantiopurity of diamines.