thiazolo[4

The antioxidant activity of novel N3 and C6 substituted 5,7-dimethyl-3H-thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The correlation analysis between the antioxidant activity and different subsets molecular descriptors was carried out for 19 compounds.

Structural modification of 5,7-dimethyl-6-phenylazo-3Н-thiazolo[4,5-b]pyridin-2-one relative to the 3rd position of basic heterocycle allows to use its functionalization as the convenient method for the synthesis of various derivatives and diversification of a series of N3 substituted thiazolo[4,5-b]pyridines. The efficient synthetic protocol for aminomethylation proceeding was developed which led to obtaining a series of novel 3-(phenylamino)-methyl derivatives of 5,7-dimethyl-6-phenylazo-3Н-thiazolo[4,5-b]pyridin-2-one.