antibiotic

The actual problem in medicine is a phenomenon of antibiotic resistance, therefore, it is expedient to develop and introduce new antibiotics or to improve the transport of already known antibiotics into the cell. PEGylating is the one of the most successful ways of improving of the delivery of therapeutic molecules to the cell, such as proteins, oligonucleotides and other biomolecules. Thus, it is promising to introduce PEG fragments into the structure of antibiotics with the preservation of their biological activity.

Chitosan films obtained from solutions in acetic acid and containing the antibiotics – cephazolin and cephotoxim – have been investigated and the principal possibility of regulating their transport properties as regards the medicinal preparations release has been demonstrated. This regulation can be carried out by films thermal modification consisting in heating of the formed films at the temperature of about 393 K and their treatment with sodium dodecylsulphate solution.