A Synthetic Approach of D-Glucose Derivatives: Spectral Characterization and Antimicrobial Studies

A new series of methyl 4,6-O-(4-methoxybenzylidene)--D-glucopyranoside derivatives was synthesized using the direct acylation method. Methyl--D-glucopyranoside was selectively converted to methyl 4,6-O-(4-methoxybenzylidene)--D-glucopyranoside by the reaction with 4-methoxybenzaldehyde dimethylacetal in a reasonable yield. Using a wide variety of acylating agents, a series of 2,3-di-O-acyl derivatives of this product was also prepared in order to gather additional information for structure elucidation.