heterocyclization

Synthesis of new derivatives of 2-acylisothiocyanate of 1-nitro-9,10-anthraquinone with antimicrobial activity

New acyl derivatives of anthraquinone by interaction of 1-nitro-2-acylisothiocyanate- anthracenedione-9,10 with glycine, 2-aminobenzoic acid, aminothiazole, 2-mercaptobenzthiazole, o- phenylenediamine, thioglycolic acid and ethyl cyanoacetate were obtained. New derivatives of 1- nitro-2-acylisothiocyanate-anthracenedione-9,10 with antimicrobial activity against Staphylococcus aureus and Candida tenuis were determined. Perspective research directions of synthesized compounds on the base on biological screening in silico  were showed.

Development of synthesis method of β-amino acid of thiophenonaphthoquinone

A convenient method of synthesis of 2-amino-4,9-dioxo-4,9-dyhidronaphto[2,3-b] thiophene-3-carboxylic acid by interaction of 2,3-dichloro-1,4-naphthoquinone with ethylcyanacetate and sulfide sodium in ethanol was developed.The influence of different factors was investigated and probable mechanism of reaction proposed. Розроблено зручний метод синтезу 2-аміно-4,9-діоксо-4,9-дигідронафто[2,3-b] тіофен-3-карбонової кислоти на основі взаємодії 2,3-дихлоро-1,4-нафтохінону з етилціаноацетатом та сульфідом натрію в етанолі.