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  3. Volume 6, Number 2
  4. DEVELOPMENT OF THE BASICS OF SPRAY TECHNOLOGY FOR EXTERNAL APPLICATION

DEVELOPMENT OF THE BASICS OF SPRAY TECHNOLOGY FOR EXTERNAL APPLICATION

CTAS.
2023;
, Number 2
: 93-101
https://doi.org/10.23939/ctas2023.02.093
Authors:
  1. Mykhailo Dronik
  2. I. Jonuškienė
  3. Maryna Stasevych
1
Lviv Polytechnic National University
2
Kaunas University of Technology, Kaunas, Lithuania
3
Lviv Polytechnic National University

The basics of the technology for the preparation of a spray formulation for external use with analgesic and anti-inflammatory effects was developed. The quantitative content of active pharmaceutical ingredients and excipients was proposed. Comparative analysis of some indicators of the obtained spray with analogues on the pharmaceutical market of Ukraine was carried out. Material calculations allowed to estimate the amount of active pharmaceutical ingredients and excipients for the preparation of the spray and its packaging in bottles with a dropper in the laboratory. Based on the material calculations, a basic technological scheme for the production of the finished product was proposed. Economic calculations have been carried out, which demonstrate a high level of economic profitability of the development of such a preparation

joint or muscle pain
spray for external use
active pharmaceutical ingredients
excipients
principle technological scheme.
  1. Harden, R. N., McCabe, C. S., Goebel, A., Massey, M., Suvar, T., Grieve, S., & Bruehl, S. (2022). Complex regional pain syndrome: practical diagnostic and treatment guidelines, 5th Edition. Pain medicine (Malden, Mass.), 23(Suppl 1), S1-S53. https://doi.org/10.1093/pm/pnac046 https://doi.org/10.1093/pm/pnac046
  2. Arévalo-Martínez, A., Moreno-Manso, J. M., García-Baamonde, M. E., Blázquez-Alonso, M., & Cantillo-Cordero, P. (2022). Psychopathological and neuropsychological disorders associated with chronic primary visceral pain: Systematic review. Frontiers in psychology, 13, 1031923. https://doi.org/10.3389/fpsyg.2022.1031923 https://doi.org/10.3389/fpsyg.2022.1031923
  3. Pohovorymo pro bilʹ: kreatyvno, tsikavo ta z posmishkoyu! Shchotyzhnevyk «Apteka», № 1266. 2020. Retrieved from URL: https://www.apteka.ua/article/573161
  4. Sobeeh, M. G., Hassan, K. A., da Silva, A. G., Youssef, E. F., Fayaz, N. A., & Mohammed, M. M. (2023). Pain mechanisms in complex regional pain syndrome: a systematic review and meta-analysis of quantitative sensory testing outcomes. Journal of orthopaedic surgery and research, 18(1), 2. https://doi.org/10.1186/s13018-022-03461-2 https://doi.org/10.1186/s13018-022-03461-2
  5. Melf-Marzi, A., Böhringer, B., Wiehle, M., & Hausteiner-Wiehle, C. (2022). Modern principles of diagnosis and treatment in complex regional pain syndrome. Deutsches Arzteblatt international, 119(51-52), 879-886. https://doi.org/10.3238/arztebl.m2022.0358 https://doi.org/10.3238/arztebl.m2022.0358
  6. NPZP ye odnymy z naybilʹsh zatrebuvanykh v Ukrayini. Shchotyzhnevyk «Apteka», 2023. Retrieved from URL: https://www.apteka.ua/article/669686
  7. Aptechnyy prodazh likiv na foni viyny. Shchotyzhnevyk «Apteka», №1345/1346, 2022. Retrieved from URL: https://www.apteka.ua/article/644822
  8. Ziesenitz, V. C., Welzel, T., van Dyk, M., Saur, P., Gorenflo, M., & van den Anker, J. N. (2022). Efficacy and safety of NSAIDs in infants: a comprehensive review of the literature of the past 20 years. Paediatric drugs, 24(6), 603-655. https://doi.org/10.1007/s40272-022-00514-1 https://doi.org/10.1007/s40272-022-00514-1
  9. Dronik, M. & Stasevych, M. (2022). Analysis of the pharmaceutical market of diclofenac preparations. Scientific Foundations in Medicine and Pharmacy, 104-123. https://doi.org/10.46299/isg.2022.mono.med.2.4.1 https://doi.org/10.46299/ISG.2022.MONO.MED.2.4.1
  10. Stasevych, M. & Viktor Zvarych (2022). Medicines of the M02AX group on the Ukrainian market: analysis of the range and search for possible market niches. The role of medical science in implementing innovative medical technologies in the EU countries and Ukraine, 292-306. https://doi.org/10.30525/978-9934-26-199-2-15 https://doi.org/10.30525/978-9934-26-199-2-15
  11. Derzhavnyy reyestr likarsʹkykh zasobiv Ukrayiny. URL: http://www.drlz.com.ua (Retrieved: 15.05.2023).
  12. Tabletki.ua. URL: https://tabletki.ua (дата звернення: 15.05.2023).
  13. Sydorov, Yu.I., Chuyeshov, V.I., & Novikov, V.P. (2009). Protsesy i aparaty khimiko-farmatsevtychnoyi promyslovosti. Vinnytsya: Nova Knyha.
  14. Ekonomika khimiko-farmatsevtychnykh pidpryyemstv: Metodychni vkazivky do vykonannya rozrakhunkiv ekonomichnoyi chastyny naukovo-doslidnoyi mahistersʹkoyi kvalifikatsiynoyi roboty dlya studentiv spetsialʹnosti 226 «Farmatsiya, promyslova farmatsiya» / Komar V.S., Baranovych D.B., Krychkovsʹka, A.M., Zhurakhivsʹka L.R., Lubenetsʹ V.I., Novikov V.P. - Vydavnytstvo kafedry TBSFB NU «Lʹvivsʹka politekhnika». - 2020. - 22 с.
  15. Kompendium - likarsʹki preparaty. URL: https://compendium.com.ua (дата звернення: 20.05.2023).
  16. Skoutakis, V. A., Carter, C. A., Mickle, T. R., Smith, V. H., Arkin, C. R., Alissandratos, J., &  Petty, D. E. (1988). Review of Diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Drug Intelligence Clinical Pharmacy, 22(11), 850-859. https://doi.org/10.1177/106002808802201102 https://doi.org/10.1177/106002808802201102
  17. Diclofenac uses, dosage and side effects. Drugs.com. (n.d.). Retrieved February 13, 2023, from https://www.drugs.com/diclofenac.html
  18. Novyy bezvodnyy rozchyn dyklofenaku mistsevoho zastosuvannya ta protses yoho pryhotuvannya: pat.97529 Ukrayina. № a201000120. zayavl. 09.06.2008; opubl. 27.02.2012, Byul. № 4.
  19. Farmatsevtychna aerozolʹna kompozytsiya u formi spreyu: pat. 81238 Ukrayina. № u2012 14971; zayavl. 26.12.2012; opubl. 25.06.2013, Byul. № 12.