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  3. Volume 17, Number 3, 2023
  4. Application of Infrared Spectroscopy and X-Ray Powder Diffractometry for Assessment of the Qualitative Composition of Components in a Pharmaceutical Formulation

Application of Infrared Spectroscopy and X-Ray Powder Diffractometry for Assessment of the Qualitative Composition of Components in a Pharmaceutical Formulation

JCCT.
2023;
Volume 17, Number 3
: pp. 510 - 517
https://doi.org/10.23939/chcht17.03.510
Authors:
  1. Maryna Stasevych
  2. Viktor Zvarych
  3. Mykhailo Dronik
  4. Martyn Sozanskyi
  5. Semen Khomyak
1
Lviv Polytechnic National University
2
Lviv Polytechnic National University
3
Lviv Polytechnic National University
4
Lviv Polytechnic National University
5
Lviv Polytechnic National University

A qualitative assessment of a new four-component pharmaceutical composition has been carried out using the methods of infrared spectroscopy and X-ray powder diffractometry. Qualitative characteristics for the identification of mixture components by absorption bands in infrared spectra and characteristic peaks by positions on the scattering angle $2\Theta$ scale in diffractograms were determined. It was experimentally confirmed that the quantitative content of benzocaine and procaine hydrochloride in the mixture without diclofenac sodium decreased by two times compared to their content in the mixture with it. Original infrared spectra and X-ray diffractograms of the new pharmaceutical composition with diclofenac sodium, which can be used for its identification, are presented.

active pharmaceutical ingredient (API)
quality composition
API mixture
infrared spectroscopy
X-ray powder diffraction
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