nucleophilic substitution reaction

Peculiarities of the course of the methanesulfo-derivatives of (benzo)imidazo[2,1-b][1,3]thiazines reac-tions with a number of nucleophilic reagents were studied. It was determined that they react nonselectively with potassium thiocyanate to form a mixture of thio- and isothiocyanate derivatives. When interacting with sodium azide, nucleophilic substitution competes with an elimination reaction. The latter is dominant in the reaction with sodium cyanide.

The most urgent task of organic and pharmaceutical chemistry today is the search for new biologically active compounds, which in future can be used as promising substances for the development of new low-toxic, high-performance medicinal products. To this end, heterocyclic N-derivatives of 1,4-dichloroanotoquinone were synthesized and their drug-like characteristics were determined.