virus mutation

An epidemic model with viral mutations and vaccine interventions

In this paper, we introduce a two-strain SIR epidemic model with viral mutation and vaccine administration.  We discuss and analyze the existence and stability of equilibrium points.  This model has three types of equilibrium points, namely disease-free equilibrium, dominance equilibrium point of strain two, and coexistence endemic equilibrium point.  The local stability of the dominance equilibrium point of strain two and coexistence endemic equilibrium point are verified by using the Routh--Hurwitz criteria, while for the global stability of the dominance equilibrium point of strain two,