The paper presents research materials related to the construction of biotechnical systems as components of cyberphysical systems of biomedical purposes. The proposed generalized structures of biomedical biotechnical systems allow us to formulate and solve the problems of designing such biotechnical systems as a component of cyberphysical systems. Considered, analyzed and proposed a number of practical measures for the creation of instrumental biotechnical systems. Features of the interaction between the biological and technical components of the list of experimental and theoretical studies, which are parallel to the technical stages of implementation. The peculiarities of constructing a biotechnical system based on bioelectroimpedance metry in terms of metrology is the impossibility of having an exemplary biological object. Errors in bioelectroimpedance measurement arise as a result of the interaction of instrumental means and biological object and the conversion of biophysical parameters into physiological characteristics. The experimental results that accompanied the development and gave the opportunity to construct a biotechnical system for determining the
level of blood loss were considered in detail.
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