Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

2017;
: pp. 437–444
Received: April 10, 2017
Revised: May 18, 2017
Accepted: September 04, 2017
1
Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México
2
Centro de Geociencias, Universidad Nacional Autónoma de México
3
Laboratorio de Neurobiologia Molecular y Celular
4
Centro de Física Aplicada y Tecnología Avanzada
5
Centro de Física Aplicada y Tecnología Avanzada
6
Centro de Física Aplicada y Tecnología Avanzada
7
Department of Materials Science and Engineering, University of North Texas

Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductively-coupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro.

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