disulfiram

Based on the bibliometric analysis of scientific publications, patents, Internet resources and previously published results of our own research, the feasibility of developing a new disulfiram composition based on graphite materials with biopolymers was substantiated. Optimal methods were selected and samples of OG-A-DS (graphene oxide-albumin-disulfiram) nanocompositions were obtained in the form of an aqueous dispersion, as well as samples of TRG-BP (thermally expanded graphite-biopolymer) compositions, which will be potential carriers for drugs.

The paper considers the possibility of creating a combined injection drug prolonged action based on naltrexone and disulfiram by encapsulation method. Polymers of poly-D, L-lactide-co-glycolide lactic acid were selected as adjuvant. Optimal method of process was developed based on the analysis of the literature, patent research and experimental data. Spheres of micro-and nano- sizes based on naltrexone and disulfiram as a powder for use as an injection were obtained.