drug release

This study examines the kinetic profiles of lidocaine hydrochloride, novocaine hydrochloride, and diclofenac sodium release from gelatin–alginate hydrogels crosslinked with poly(ethylene glycol) diglycidyl ether. Drug release was evaluated in phosphate-buffered saline (PBS) and in PBS supplemented with a proteolytic enzyme using a Franz diffusion cell. The experimental data were fitted to zero-order and first-order kinetic models, as well as the Higuchi, Hixson–Crowell, and Korsmeyer–Peppas models.

The article presents the conditions of synthesis and the results of characterization of the obtained gelatin and gelatin-alginate hydrogels structured with polypropylene glycol diepoxide. The swelling in water, saline, and model exudate was studied, and the gel fraction and tensile strength of the synthesized samples were determined. The regularities of saturation with drugs and their release into model environments were obtained.

The principal opportunity of uptaking weakly crosslinked hydrogel emboli is shown by Doxorubicin at different temperatures. The optimal process time is 1.5–2.5 h. It is revealed that Doxorubicin is capable to diffuse from a polymeric matrix, having targeted medical effect on surrounding tissue and reducing side impacts on other organs.