електрофільна внутрішньомолекулярна циклізація

Synthesis, Antimicrobial and Antioxidant Activity of 3-Aryl-6,7-Dihydro-5H-[1,3]Thiazolo[3,2-a]Pyrimidines

A series of 3-aryl-6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidines was obtained by cyclocondensation of tetrahydropyrimidin-2(1H)-one with 2-bromo-1-arylethanones. It was established that the nature of the substituent in the aromatic nucleus of phenacyl bromide significantly affects the course of this type of reaction.

Electrophilic Intramolecular Cyclization of 1-(N-alkenyl)-6-methylpyrimidine-2,4-diones

N-allyl(cinnamyl)substituted derivatives of 6-methyluracil were synthesized. The reactions of their bromo- and iodocyclization were performed which led to the formation of the derivatives of dihydro¬oxazolo¬pyrimidinium and dihydrooxazinepyrimidinium. The factors that favor the regioselectivity of these reactions were suggested.