Receiving Elastoviscous Systems on the Basis of Aqueous Solution of Acetate and Succinimide of Chitosan in the Presence of Polyhydric Alcohols

The rheological behavior of acetate and succinimide of chitosan in mixed solvents was investigated. It is shown that the replacement of a part of the solvent by two- or three-atom alcohols is accompanied by an increase in the relative and dynamic viscosity of the succinimide chitosan solution, an earlier formation of the net of links, a transition from viscoelastic systems to elastoviscous ones at lower polymer concentration values and an increase in the relaxation time.

Biocompatible Gel-like Forms of Drugs on the Basis of Solutions of Polysaccharide Chitosan with Alcohols

We propose an approach to the preparation of viscoelastic systems based on chitosan without crosslinking agents. It is the formation of an additional network of physical links by introducing a low molecular weight modifier – ethanol or glycerol. It turns out that gelation of chitosan in the solution is accompanied by the formation of additional meshes of physical links, nodes or aggregates of chitosan macromolecules formed in a mixed solvent of acetic acid-water-glycerol or acetic acid-waterethanol.