Solubility of Ibuprofen in Conventional Solvents and Supercritical CO2: Evaluation of Ideal and Non-Ideal Models
In this study solubility of racemic (R/S)(±)-ibuprofen in pure conventional solvents (n-heptane, toluene, benzene and ethanol) and supercritical carbon dioxide is predicted and the results are compared with experimental data. The results of the ideal solubility show great deviation from experimental points. However, it seems that liquid phase non-ideality is the main problem in the modeling of this system. To capture the non-ideality of the system UNIQUAC, UNIFAC, NRTL, Wilson, and regular-solution theory are used.