In a continued search for new medicinally active nonlinear phenothiazines, novel angular chloroazaphenothiazinone derivatives have been synthesized via transition metal-catalyzed cross-coupling reactions. The structural elucidation of the synthesized compounds was established by a combined spectroscopic and elemental analysis.
The synthesis and anticancer activity of a series of new 3-amido derivatives of 3-chloro-10H-pyrido[3,2-b][1,4]benzoxazine and 3-chloro-10H-pyrido[3,2-b][1,4]benzothiazine is presented. The synthesized structures were characterized by UV-visible, FT-IR, 1H NMR spectroscopy and elemental analytical data. The in silico physicochemical properties disclosed that neither 3-chloro-10H-pyrido[3,2-b][1,4]benzoxazine and 3-chloro-10H-pyrido[3,2-b][1,4]benzothiazine intermediates nor their carboxyamido derivatives violate Lipinski’s rule of five.