Еvaluation of cytotoxicity of heterocyclic aminocontaining 1,4-naphthoquinone derivatives
The cytotoxic activity of heterocyclic amino-containing derivatives of 1,4-naphthoquinone in vitro on various human breast cancer lines, namely: MDA-MB, MCF-7, SK-BR-3, BT-474 and non-cancerous cell lines (MCF-10A) was investigated. In silico prediction of toxicity of the test substances for rats was performed using modern software ProTox-II. It was established that all studied compounds belong to toxicity classes IV and VI and are of low toxicity.