Pudovik reaction

A Methodology Study of Hydrophosphonylation of Aldehydes Derivatives with H6P2W18O62•14H2O as a Catalyst

A catalytic process for hydrophosphonylation of aldehydes with H6P2W18O62•14H2O has been developed in this paper. Various aldehydes were reacted with diethylphosphite in the presence of 1 % of heteropolyacids (HPAs) as a catalyst to generate the α-hydroxyphosphonates. All the synthesized compounds were systematically characterized by IR, 1H NMR, 13C NMR, and 31P NMR.