Influence of σ Donation and π Acceptance Properties of Spectator Ligands on Substitution Reactions in Bifunctional Mononuclear Platinum(II) Complexes: Exploring Reactivity Pattern of Antitumor Compound
Kinetics and mechanism of ligand substitution reactions on square planar platinum (II) complexes have been explored continuously over the last few decades. This was after the fortuitous discovery of the antiproliferative activity of cisplatin by Barnett Rosenberg in 1965, which attracted much attention from various other investigators to design new Pt(II) drugs with better activity and fewer side effects. Cisplatin's clinical success as a chemotherapeutic drug has promoted the discovery of succeeding generations with efficacy and less toxicity.