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  2. All Volumes and Issues
  3. Volume 17, Number 2, 2023
  4. Strategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles

Strategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles

JCCT.
2023;
Volume 17, Number 2
: pp. 294 - 303
https://doi.org/10.23939/chcht17.02.294
Authors:
  1. Dmytro Khomenko
  2. Tetyana Shokol
  3. Roman Doroshchuk
  4. Ilona Raspertova
  5. Rostyslav Lampeka
  6. Yulian Volovenko
1
Department of Chemistry, Taras Shevchenko National University of Kyiv
2
Department of Chemistry, Taras Shevchenko National University of Kyiv
3
Department of Chemistry, Taras Shevchenko National University of Kyiv
4
Department of Chemistry, Taras Shevchenko National University of Kyiv
5
Department of Chemistry, Taras Shevchenko National University of Kyiv
6
Department of Chemistry, Taras Shevchenko National University of Kyiv

Conjugated heterocyclic compounds with a 1,2,4-triazole core are of scientific interest due to their wide application in both synthetic and medicinal chemistry. In this review, we comprehensively summarize the synthetic methods for [1,2,4]triazolo[1,5-a]pyridine-8-carbonitriles. The methods are classified as follows: convertion of 8-substituted [1,2,4]triazolo[1,5-a]pyridines; synthesis based on functionalized pyridines, containing a nitrile group; synthesis based on heterocyclization of 2-(1,2,4-triazol-5-yl)acetonitriles, including cyclocondensation of 2-(1,2,4-triazol-5-yl)acetonitriles with β-dicarbonyl compounds and heterocyclization of 2-(1,2,4-triazol-5-yl)acetonitriles with α,β-unsaturated nitriles and esters; cyclocondensation of acyclic reagents, namely hydrazine derivatives and substituted methylenemalononitriles or their precursors and recyclization of oxadiazolopyridi-nium salts upon the interaction with ammonia or amine.

aminopyridines
condensation
hydrazine derivatives
[1,2,4]triazolo[1,5-a]pyridine-8-carbonitriles
2-(1H-1,2,4-triazol-5-yl)acetonitrile
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