1. JCCT
  2. Всі випуски
  3. Випуск 17, Номер 2, 2023
  4. Стратегії синтезу [1,2,4]триазоло [1,5-a]піридин-8-карбонітрилів

Стратегії синтезу [1,2,4]триазоло [1,5-a]піридин-8-карбонітрилів

JCCT.
2023;
Випуск 17, Номер 2
: cc. 294 - 303
https://doi.org/10.23939/chcht17.02.294
Автори:
  1. Dmytro Khomenko
  2. Tetyana Shokol
  3. Roman Doroshchuk
  4. Ilona Raspertova
  5. Rostyslav Lampeka
  6. Yulian Volovenko
1
Department of Chemistry, Taras Shevchenko National University of Kyiv
2
Department of Chemistry, Taras Shevchenko National University of Kyiv
3
Department of Chemistry, Taras Shevchenko National University of Kyiv
4
Department of Chemistry, Taras Shevchenko National University of Kyiv
5
Department of Chemistry, Taras Shevchenko National University of Kyiv
6
Department of Chemistry, Taras Shevchenko National University of Kyiv

Конденсовані гетероциклічні сполуки, що містять 1,2,4-триазольний цикл, представляють інтерес для науковців у зв’язку з їхнім широким застосуванням як у синтетичній, так і в медичній хімії. У цьому огляді було вичерпно узагальнено методи синтезу [1,2,4]триазоло[1,5-a]піридин-8-карбонітрилів та класифіковано за типами використовуваних реагентів: перетворення 8-заміщених [1,2,4]три-азоло[1,5-a]піридинів; синтези на основі функціоналізованих піридинів, що містять нітрильну групу; синтези на основі гетероциклізації 2-(1,2,4-триазол-5-іл)ацетонітрилів, включаючи циклоконденсації 2-(1,2,4-триазол-5-іл)ацетонітрилів з β-дикарбонільними сполуками та гетероциклізації 2-(1,2,4-триазол-5-іл)ацетонітрилів з α,β-ненасиченими нітрилами та естерами; циклоконденсації ациклічних реагентів, а саме похідних гідразину та заміщених метиленмалононітрилів або їхніх прекурсорів і рециклізацію солей оксадіазолопіридинію під дією аміаку або амінів.

амінопіридини
конденсація
похідні гідразину
[1,2,4]триазоло[1,5-a]піридин-8-карбонітрили
2-(1H- 1,2,4-триазол-5-іл)ацетонітрил
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