The article considers the role of color as one of the most important tools of the biophilic approach in the design of living space. Color is analyzed not as a decorative element, but as a full-fledged factor of psychophysiological comfort and harmonious climate of premises. Based on the generalization of scientific research in environmental psychology, neurodesign and architectural theory, it is shown that natural colors reduce stress, support concentration, improve mood and can give a sense of security. Special attention is paid to the concept of "color scenarios" in living space, which takes into account the functional purpose of premises, daily human biorhythm and cultural codes. The article emphasizes the importance of the interaction of color with materials and lighting, because it is this synergy that creates a full-fledged biophilic experience. An important contribution is the proposal of a methodology for evaluating color as a criterion of biophilia, which involves a multilevel approach: psychophysiological (measurement of emotional and physiological reactions), functional (compliance with the spatial scenario), cultural and symbolic (connection with local tradition). Criteria and indicators are proposed that can be used in design practice and integrated into international standards of sustainable construction. The article also highlights the possibilities of applying modern research methods – from neuropsychological (EEG, fMRI, eye tracking) to computer modeling in VR environments, which provide an objective assessment of the impact of color solutions on a person. Thus, it is proven that color in a biophilic interior is a multidimensional phenomenon that combines archetypes of nature, physiological mechanisms of influence and cultural meanings. Its systematic study and implementation in design practice can be an important contribution to the creation of a healthy, individualized and ecological living environment.