curcumin

This review focuses on amphiphilic diesters and "gemini" surfactants synthesized from pyromellitic acid, polyethylene glycols, aliphatic alcohols, and cholesterol. The discussion encompasses their unique colloidal and chemical properties, with an emphasis on the relationship between critical micelle concentration and hydrophilic-lipophilic balance. Structural factors, particularly the length of the lipophilic substituents, significantly influence CMC values in aqueous systems.

The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin.