Synthesis and Selfassambling of Amphiphilic Oligoesters Based on Pyromellitic Acid

Authors:

Ihor Tarnavchyk, Andriy Voronov, Volodymyr Donchak, Olga Budishevska, Olena Kudina, Olena Khomenko, Khrystyna Harhay, Volodymyr Samaryk and Stanislav Voronov

Ihor Tarnavchyk-1, Andriy Voronov-1, Volodymyr Donchak-2, Olga Budishevska-2, Olena Kudina-1, Olena Khomenko-2, Khrystyna Harhay-2, Volodymyr Samaryk-2 and Stanislav Voronov-2

North Dakota State University, Dept. 2760, P.O. Box 6050, Fargo, ND 58108-6050, USA; andriy.voronov@ndsu.edu
Lviv Polytechnic National University; 12, S. Bandery str., 79013 Lviv, Ukraine; donchak@polynet.lviv.ua

The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin. The high solubilization capacity of the OEPA assemblies and their biodegradability, as well as other properties (size distribution, ζ-potential) make the oligoesters considered as promising materials for the design of drug delivery systems.

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