antifungal

In this study, a series of new1,2,5-oxadiazole compounds derived from 4-chloro-7-nitro-benzo 1,2,5-oxadiazole was synthesized using different organic procedures. The resulting derivatives were chemically characterized and their structures were confirmed by FT-IR and NMR analysis. All the compounds were also evaluated for their antibacterial and antifungal activity against four types of pathogenic bacteria: S.aureus, S.epidermidis (as gram-negative bacteria), E.coli, Klebsiella spp. (as gram-positive bacteria) and the fungus Candida albicans using the agar well diffusion method.

A new series of methyl 4,6-O-(4-methoxybenzylidene)--D-glucopyranoside derivatives was synthesized using the direct acylation method. Methyl--D-glucopyranoside was selectively converted to methyl 4,6-O-(4-methoxybenzylidene)--D-glucopyranoside by the reaction with 4-methoxybenzaldehyde dimethylacetal in a reasonable yield. Using a wide variety of acylating agents, a series of 2,3-di-O-acyl derivatives of this product was also prepared in order to gather additional information for structure elucidation.