Development of the technological basis for the production of aceclofenac
Aceclofenac drugs are widely used in the global therapeutic practice of inflammatory and painful conditions for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in various dosage forms. The basics of the technology of domestic industrial batch production of aceclofenac with a capacity of 110 t/year for the production of a number of effective medicines have been developed. A five-stage production process is proposed that will allow the production of a domestic product with a high yield (~ 91%) from commercially available reagents.