Pyrimidine and its derivatives are important objects for chemical synthesis and development of new drugs based on them. There is a practical application of a number of substances with a pyrimidine heterocycle in medical practice. We performed a predicted screening of biological activity, cytotoxicity and toxicity in rats of some synthesized pyrimidine thiosulfonates using appropriate on-line programs.
MgFe2O4 nanoparticle ferrites were synthesized by combustion technique using pure ferric nitrate and magnesium nitratecarbonate. The magnetically separable MgFe2O4 MNP’s were found to be hyper active catalyst for the synthesis of a wide range of biologically active five and six-membered heterocyclic moieties at refluxing conditions. Reaction times are lowest in comparison to all reported in literature with excellent yields. Strong electron pull of Fe3+ is responsible for its hyper activity, which has been substantiated by substitution of Fe3+ by other trivalent metal ions.