This article presents the results of numerical modeling and experimental prototyping of an acoustofluidic microchannel structure for the separation of microparticles suspended in a liquid medium. A two-dimensional model was developed to analyze the influence of geometric and physical parameters on the formation of the acoustic field within the microchannel and the efficiency of particle separation. Special attention was given to the configuration of interdigital transducers (IDT), channel width, thickness of the piezoelectric substrate, and the distance between the IDT and the channel. Based on the simulation results, a Lab-on-Chip prototype was fabricated using a silicon substrate, lithium niobate plate, and silver paste to form IDT electrodes via screen printing. A bonding method using double-sided adhesive tape was proposed to ensure tight sealing of the microchannels. The results confirm the potential of the proposed approach for developing compact acoustofluidic systems suitable for biomedical, environmental, and analytical applications
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