Predictive screening of the biological activity of S-alkyl esters of 8-quinolinsulfonic acid

: 125-134
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic
Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University
Lviv Polytechnic National University
Lviv Polytechnic National University
Lviv Polytechnic National University

Quinoline and its derivatives are important compounds for the chemical synthesis and development of novel drugs. Practical application of a number of substances with quinoline heterocycle is already known in medical practice. We performed predictive screening for biological activity, cytotoxic and toxic effects on rats of synthesized 8-quinoline thiosulfonic acid S-alkyl esters using appropriate on-line programs.They have been found to be low-toxic substances with a broad spectrum of biological action and a high probability of activity, which indicates the expediency of continuing experimental studies of their properties. Particular attention should be paid to the methyl and ethyl esters of 8-quinolintiosulfonic acids.

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