toxicity

PREDICTED SCREENING OF BIOLOGICAL ACTIVITY OF THIOSULPHONATE PYRIMIDINE DERIVATIVES

Pyrimidine and its derivatives are important objects for chemical synthesis and development of new drugs based on them. There is a practical application of a number of substances with a pyrimidine heterocycle in medical practice. We performed a predicted screening of biological activity, cytotoxicity and toxicity in rats of some synthesized pyrimidine thiosulfonates using appropriate on-line programs.

PROBLEM OF DISPOSAL OF ORGANOCHLORINE WASTE OF VINYL CHLORIDE PRODUCTION

The sources of organochlorine waste formation, its toxicity, and environmental impact are analyzed, and methods of its disposal are considered. The composition of insoluble compounds in the stillage residues of the dichloroethane rectification stage before incineration is determined, and the method of their extraction is proposed.

INFLUENCE OF PETROL AND PETROLEUM COMPONENTS’ VAPOURS ON HUMAN ORGANISM

The work deals with the analysis of sources and ingression of petroleum vapours into environment, as well as with petrol losses and the dependence of the vapours concentration on the tank volume and the ambient temperature. The concentration of petroleum vapours at the petrol station and the individual risk of hazard level have been calculated. The chemical composition of petrol is shown, toxicity of its components and their influence on the human organism as a whole are analyzed.

Dependence of Phenol Toxicity on Kind and Position of Substitutes

Toxicity of 28 phenol derivatives with different alkyl substitutes in 2-, 6-positions and NH2 , CN, ОН functional groups in 4-position was studied. The least toxicity has phenols with two tert-butyl substitutes in o-position. The toxicity increases with functional p-substitutes removal from benzene nuclei. The obtained results can help to synthesize new nontoxic bioactive phenols.