A Green and Efficient Solvent- and Catalyst-Free Ultrasonic Dibenzylation Procedure

: pp. 126–132
Saveh University of Medical Sciences
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University
Active PharmaceuticalIngredients Research Center, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS)

A greener improvement was achieved for the synthesis of diverse N,N-dibenzylated compounds from the reaction of various aromatic amines with benzyl bromide using the ultrasound irradiation in solvent- and catalyst-free conditions. The dibenzylation reactions were carried out in different solvents and solvent-free conditions under ultrasound irradiation at various temperatures. The yields were very low in all applied solvents, while in the solvent-free condition and at room temperature, the yields were excellent. Due to obtaining the high reaction yields, the catalyst was not used.

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